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A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis

Jorge Esparza-Gordillo1, Heidi Schaarschmidt, Liming Liang

  • 1Pediatric Allergology, Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany.

The Journal of Allergy and Clinical Immunology
|April 16, 2013
PubMed
Summary

Genetic variants influence atopic dermatitis (AD) risk. A specific IL-6 receptor variant (rs2228145) is linked to persistent AD and increased soluble IL-6 receptor levels.

Keywords:
ADALSPACAtopic dermatitisAvon Longitudinal Study of Parents and ChildrenGWASGenome-wide association studyIL-6 receptorIL-6RMASMulticenter Allergy StudyOROdds ratioSNPSingle nucleotide polymorphismcandidate association studygenetic risk factorinflammationlongitudinal studypersistent atopic dermatitispopulation-based cohortprognosissingle nucleotide polymorphismsoluble IL-6 receptor

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