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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

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Published on: April 1, 2015

The skin and hypercoagulable states.

Laura A Thornsberry¹, Kristen I LoSicco, Joseph C English

¹Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

Journal of the American Academy of Dermatology

|April 16, 2013

Summary

This summary is machine-generated.

Dermatologists can identify hypercoagulable states (HS) by recognizing specific skin conditions. Early detection of these cutaneous manifestations aids in diagnosing thrombophilic disorders and guiding treatment.

Keywords:

APC APLA APLS CVU DIC DVT HIT HS LMWH LR LV PE PF SVT TF TTP VTE activated protein C anetoderma antiphospholipid antibody antiphospholipid antibody syndrome chronic venous ulcer chronic venous ulceration deep venous thrombosis disseminated intravascular coagulation hemostasis heparin-induced thrombocytopenia hypercoagulable states livedo reticularis livedo vasculopathy low-molecular-weight heparin pulmonary embolism purpura purpura fulminans superficial venous thrombosis thrombosis thrombotic thrombocytopenic purpura tissue factor venous thromboembolism

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Area of Science:

Dermatology
Hematology
Vascular Medicine

Background:

Hypercoagulable states (HS) increase the risk of venous and arterial thrombosis.
Dermatologists can play a key role in identifying HS through cutaneous manifestations.
Associated skin findings include purpura, livedo reticularis, and chronic venous ulcers.

Purpose of the Study:

To review the role of dermatologists in diagnosing hypercoagulable states.
To discuss the basic science of hemostasis and evaluation of HS.
To highlight skin manifestations and therapeutic options in dermatology.

Main Methods:

Literature review focusing on hemostasis, HS, cutaneous signs, and therapies.
Analysis of diagnostic roles of dermatologists in identifying thrombophilic disorders.
Discussion of antiplatelet and anticoagulant therapies in dermatological practice.

Main Results:

Cutaneous manifestations are often nonspecific but can indicate underlying HS.
Recognition of specific skin findings prompts further investigation for thrombophilia.
Dermatologists are crucial in the initial diagnostic pathway for HS.

Conclusions:

Dermatologists can significantly contribute to the early diagnosis of hypercoagulable states.
Understanding skin manifestations of HS is vital for timely thrombophilia workup.
Appropriate management involves considering antiplatelet and anticoagulant therapies.