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Related Experiment Video

Updated: May 12, 2026

Detection and Analysis of DNA Damage in Mouse Skeletal Muscle In Situ Using the TUNEL Method
09:54

Detection and Analysis of DNA Damage in Mouse Skeletal Muscle In Situ Using the TUNEL Method

Published on: December 16, 2014

[Contribution of the TUNEL method for post-mortem interval estimation: an experimental study].

Anne Dorandeu1, Geoffroy Lorin de la Grandmaison

  • 1Service de médecine légale, hôpital Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.

Annales De Pathologie
|April 16, 2013
PubMed
Summary
This summary is machine-generated.

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Forensic pathology benefits from a new method to estimate time since death. The TUNEL assay reveals apoptosis in skin cells, correlating with the post-mortem interval up to 48 hours.

Area of Science:

  • Forensic pathology
  • Cell biology
  • Biomarkers

Context:

  • Accurate post-mortem interval (PMI) estimation is crucial in forensic investigations.
  • Current methods for early PMI assessment are often imprecise.
  • Apoptosis, or programmed cell death, is a cellular process that may change predictably after death.

Purpose:

  • To investigate the relationship between apoptosis rates and the post-mortem interval.
  • To evaluate the utility of the Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) method for PMI estimation.

Summary:

  • The study applied the TUNEL method to rat skin samples to quantify apoptotic cells.
  • A statistically significant correlation was observed between the rate of apoptosis and the post-mortem interval within the first 48 hours post-mortem.

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Last Updated: May 12, 2026

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  • Post-mortem processes were found to induce apoptosis in skin cells.

    • Impact:

    • The TUNEL method shows potential as a more precise tool for estimating early post-mortem intervals.
    • This research contributes to the development of objective biomarkers for forensic science.
    • Findings may improve the accuracy of time-of-death estimations in legal investigations.