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Published on: February 10, 2015
[Ischemic cholangiopathy induced by extended burns]
Laurence Cohen1, Emilie Angot, Odile Goria
1Service d'anatomie et de cytologie pathologiques, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
Annales De Pathologie
|April 16, 2013
Summary
Ischemic cholangiopathy is a rare condition that can occur after severe burn injuries. This case highlights a patient developing jaundice and biliary cirrhosis following intensive care unit treatment for extensive burns.
Area of Science:
- Hepatology
- Gastroenterology
- Critical Care Medicine
Background:
- Ischemic cholangiopathy (IC) is a serious biliary complication primarily observed post-hepatic transplantation.
- Cases of IC following intensive care unit (ICU) stays for extensive burn injuries are exceptionally rare.
Observation:
- A 73-year-old woman presented with jaundice and progressive biliary lesions after ICU treatment for severe burns.
- Initial biological tests were unremarkable, and the patient had no prior history of liver or biliary disease.
Findings:
- Magnetic resonance imaging revealed diffuse, severe stenosing lesions characteristic of cholangiopathy, predominantly affecting the peri-hilar intrahepatic biliary tract.
- Liver biopsy confirmed biliary cirrhosis with bile infarcts, establishing the diagnosis of ischemic cholangiopathy.
Implications:
- This report represents the fourth documented instance of ischemic cholangiopathy developing after extensive burn injury in a patient without pre-existing hepatic or biliary conditions.
- The case underscores the potential for ICU-acquired ischemic cholangiopathy in burn patients, necessitating increased clinical awareness.
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