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Related Experiment Videos

[Woronoff rings in a mathematical model].

G Groebe1, W C Marsch, H Holzmann

  • 1Zentrum der Dermatologie und Venerologie, Johann Wolfgang Goethe-Universität Frankfurt am Main.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|April 1, 1990
PubMed
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The width of a Woronoff ring is not constant for all lesion sizes, contrary to previous assumptions. This study suggests a mediator diffuses from psoriatic plaques, influencing the ring

Area of Science:

  • Dermatology and mathematical modeling.
  • Investigating the pathogenetic mechanisms of psoriatic lesions.

Context:

  • The Woronoff ring, a clinical sign in psoriasis, has been traditionally considered to have a constant width.
  • Previous understanding did not account for lesion size dependency.

Purpose:

  • To investigate the relationship between Woronoff ring width and lesion diameter.
  • To test the hypothesis that a mediator diffuses from psoriatic plaques.
  • To develop a mathematical model explaining the observed phenomena.

Summary:

  • Clinical observations indicate Woronoff ring width is constant only for lesions above a minimum size.
  • A hypothetical mediator diffusing from psoriatic plaques is proposed as the cause of the pale area within the ring.
  • A mathematical model supports this hypothesis and allows for derivation of mediator properties.

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Impact:

  • Challenges the established view of Woronoff ring characteristics.
  • Provides a potential pathogenetic explanation for the Woronoff ring.
  • Offers a framework for further research into the hypothetical mediator in psoriasis.