Thermal stability of oligodeoxynucleotide duplexes containing l-deoxynucleotide at termini
Hidehito Urata1, Shuji Ogawa, Shun-Ichi Wada
1Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. urata@gly.oups.ac.jp
Bioorganic & Medicinal Chemistry Letters
|April 16, 2013
Abstract:
The effects of substituting l-deoxynucleotide for d-deoxynucleotide at duplex termini were evaluated and the terminal substitutions were found to show much less effects on duplex destabilization and to show a similar tendency in base pairing selectivity, compared with internal chiral substitutions.
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