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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

Updated: May 12, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Insights into mast cell functions in asthma using mouse models.

Ying Lei1, Joshua A Gregory, Gunnar P Nilsson

  • 1Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Pulmonary Pharmacology & Therapeutics
|April 16, 2013
PubMed
Summary

Asthma mouse models often fail to predict human treatment outcomes because they lack sufficient mast cells. New models using mast cell-deficient mice better mimic human asthma, improving therapeutic development.

Keywords:
Airway hyperresponsivenessEngraftementInflammationMast cellsMouse asthma models

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Area of Science:

  • Immunology and Respiratory Medicine
  • Translational Asthma Research

Background:

  • Asthma therapeutics successful in mouse models often fail in human clinical trials.
  • Current asthma mouse models inadequately represent mast cell involvement, crucial in human asthma pathogenesis.
  • Wild type mice have limited mast cells in small airways, unlike humans, hindering model relevance.

Purpose of the Study:

  • To investigate the role of mast cells in asthma pathogenesis using advanced mouse models.
  • To review mast cell-dependent and -independent responses in asthma models.
  • To highlight the utility of mast cell-deficient and engrafted mice for improved asthma research.

Main Methods:

  • Utilized mast cell-deficient mice and mast cell-engrafted mice to create novel asthma models.
  • Compared mast cell distribution in these models to that observed in human subjects.
  • Reviewed mast cell-dependent and -independent airway hyperresponsiveness and inflammation.

Main Results:

  • Mast cell-deficient mice engrafted with mast cells exhibit a mast cell distribution more akin to humans.
  • These advanced models allow for a more accurate assessment of mast cell roles in asthma.
  • Distinguishes between mast cell-dependent and -independent mechanisms contributing to asthma symptoms.

Conclusions:

  • Current asthma mouse models require refinement to better reflect human disease, particularly regarding mast cells.
  • Mast cell-deficient and engrafted mouse models offer a promising platform for developing effective asthma therapeutics.
  • Further research focusing on mast cell involvement is critical for advancing asthma treatment strategies.