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Updated: May 12, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
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Synthesis methods for nanosized hydroxyapatite with diverse structures.

Mehdi Sadat-Shojai1, Mohammad-Taghi Khorasani, Ehsan Dinpanah-Khoshdargi

  • 1Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965/115 Tehran, Iran. MSadatShojai@gmail.com

Acta Biomaterialia
|April 16, 2013
PubMed
Summary

Hydroxyapatite (HAp) nanoparticles enhance biomaterials. This review details various synthesis methods for HAp, evaluating their pros and cons for controlled powder preparation.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Hydroxyapatite (HAp) is the primary mineral component of vertebrate bones and teeth.
  • HAp nanoparticles are crucial for improving the biocompatibility and bioactivity of synthetic biomaterials.
  • Demand for HAp nanoparticles has surged, driving the development of diverse synthetic routes.

Purpose of the Study:

  • To comprehensively review and summarize existing preparation methodologies for hydroxyapatite (HAp) nanoparticles.
  • To critically analyze the advantages and disadvantages of each synthesis method.
  • To identify key challenges and future research directions in HAp nanoparticle synthesis.

Main Methods:

  • Literature review of various HAp nanoparticle synthesis techniques.

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  • Comparative analysis of different processing parameters and their impact on HAp properties.
  • Inclusion of recent findings on both nanosized and microsized HAp particles.

    • Main Results:

    • Multiple synthetic routes for HAp nanoparticles exist, each with unique scientific and economic implications.
    • Controlling critical HAp properties is achievable by adjusting processing parameters.
    • A wide array of methods makes selecting a specific procedure for well-defined HAp powder challenging.

    Conclusions:

    • A thorough understanding of HAp synthesis methods is essential for researchers and material scientists.
    • Further research is needed to address critical issues and challenges in HAp nanoparticle production.
    • This review provides a valuable resource for selecting appropriate HAp synthesis strategies.