Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.

Aging cell·2026
Same author

First-in-human EphA2-targeting PET imaging with the bicyclic radiotracer [<sup>68</sup>Ga]Ga-BCY18469 in pancreatic cancer patients: biodistribution, dosimetry and initial findings.

European journal of nuclear medicine and molecular imaging·2026
Same author

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

The Journal of pathology·2026
Same author

Machine Learning Models for Objective Assessment of Vascular Anastomoses Using Computational Fluid Dynamics for Surgical Skill Training-A Retrospective Study.

Journal of clinical medicine·2026
Same author

Clinical impact of molecular tumor board inclusion on treatment outcomes in neuroendocrine neoplasms.

Neuroendocrinology·2026
Same author

CD155-CD96 keeps quiescent persister tumor cells in check.

Developmental cell·2026
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 orchestrates O-glycosylated IL-6 secretion to drive pancreatic fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply to "Methodological Considerations on Neonatal Metabolomics and Future Inflammatory Bowel Disease".

Gastroenterology·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

The gastrointestinal tumor microenvironment.

Michael Quante1, Julia Varga2, Timothy C Wang3

  • 1II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.

Gastroenterology
|April 16, 2013
PubMed
Summary
This summary is machine-generated.

The gastrointestinal tumor microenvironment, crucial for cancer growth and spread, involves complex interactions between epithelial, stromal, and immune cells. Understanding this network offers new therapeutic avenues for gastrointestinal cancers.

More Related Videos

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

Related Experiment Videos

Last Updated: May 12, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

Area of Science:

  • Oncology
  • Gastroenterology
  • Cancer Biology

Background:

  • The tumor microenvironment is increasingly recognized as a critical factor in gastrointestinal cancer development and progression.
  • Traditionally, therapies focused on cancer cells, but interactions within the microenvironment are now gaining attention.

Purpose of the Study:

  • To review the cellular components of the gastrointestinal tumor microenvironment.
  • To discuss their functions in carcinogenesis.
  • To explore the potential of targeting the stromal network for novel therapeutic strategies.

Main Methods:

  • Literature review of studies on gastrointestinal tumor microenvironment.
  • Analysis of cellular interactions in carcinogenesis.
  • Discussion of therapeutic implications of stromal network understanding.

Main Results:

  • The gastrointestinal tumor microenvironment comprises diverse cellular components influencing tumor initiation, progression, and metastasis.
  • Interactions among epithelial, stromal, and immune cells are key drivers of gastrointestinal carcinogenesis.
  • The stromal network plays a significant role in tumor progression.

Conclusions:

  • A comprehensive understanding of the gastrointestinal tumor microenvironment is essential for advancing cancer therapy.
  • Targeting the complex stromal network presents a promising strategy for developing new treatments for gastrointestinal cancers.
  • Future research should focus on elucidating these interactions to develop effective therapeutic interventions.