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Microarray analysis of microRNA expression in liver cancer tissues and normal control

Lianjie Lin1, Yan Lin, Yu Jin

  • 1Department of Gastroenterology and Hepatology, Shengjing Hospital of China Medical University, 36 Sanhao, Heping, Shenyang 110004, China. audreylin73@hotmail.com

Gene
|April 16, 2013
PubMed
Abstract

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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