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Updated: May 12, 2026

Near-Infrared Spectroscopy During Reactive Hyperemia for the Assessment of Lower Limb Vascular Function
Published on: March 22, 2024
Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia
Hsien-Tsai Wu1, Po-Chun Hsu, Cheuk-Kwan Sun
1Department of Electrical Engineering, National Dong Hwa University, Hualien, Taiwan.
Abstract:
It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak-peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR₁₋₁₀ was noted only in patients with diabetes. Moreover, a significient correlation between SSR₁₋₁₀ and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR₁₋₁₀ after RH in patients with diabetes; and, a significient correlation between SSR₁₋₁₀ and endothelial function at the moment of RH was noted.
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