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Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...

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Updated: May 12, 2026

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Stress, epigenetics, and alcoholism.

Sachin Moonat¹, Subhash C Pandey

¹University of Illinois, Chicago, IL, USA.

Alcohol Research : Current Reviews

|April 16, 2013

Summary

Stress and alcohol use disorder are linked, with brain-derived neurotrophic factor (BDNF) playing a key role. Epigenetic mechanisms may control BDNF signaling, offering insights into stress and alcoholism interactions.

Area of Science:

Neuroscience
Psychiatry
Molecular Biology

Background:

Stress and anxiety are linked to psychiatric disorders and alcoholism.
Alcohol consumption can temporarily alleviate dysphoria, contributing to its use.
Brain-derived neurotrophic factor (BDNF) is crucial for synaptic plasticity and implicated in stress and alcoholism.

Purpose of the Study:

To explore the role of brain-derived neurotrophic factor (BDNF) in mediating the relationship between stress and alcohol consumption.
To investigate the involvement of epigenetic mechanisms in regulating BDNF signaling and synaptic plasticity.
To understand the neurobiological underpinnings of stress-related disorders and alcoholism.

Main Methods:

Review of existing literature on stress, anxiety, alcoholism, BDNF, and epigenetics.

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Analysis of studies investigating the regulation of BDNF signaling pathways.

Examination of research on epigenetic modifications (e.g., chromatin remodeling) affecting gene expression.

Main Results:

Aberrant BDNF signaling and altered synaptic plasticity are associated with stress-related disorders and alcoholism.
Epigenetic mechanisms, such as chromatin modification, are implicated in controlling BDNF signaling.
These epigenetic processes may modulate gene expression relevant to stress and alcohol dependence.

Conclusions:

Epigenetic regulation of BDNF signaling and synaptic plasticity is a promising area for understanding the link between stress and alcoholism.
Targeting epigenetic mechanisms could offer novel therapeutic strategies for stress-related psychiatric disorders and alcohol use disorder.
Further research into the intricate interplay of stress, BDNF, epigenetics, and alcoholism is warranted.