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Related Experiment Videos

Aqueous humor pH changes after experimental alkali burns.

C A Paterson, R R Pfister, R A Levinson

    American Journal of Ophthalmology
    |March 1, 1975
    PubMed
    Summary

    Alkali burns to the eye significantly increase aqueous humor pH. Prompt paracentesis and anterior chamber reformation with sterile solutions are recommended for treating severe alkali eye burns.

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    Area of Science:

    • Ophthalmology
    • Toxicology
    • Physiology

    Background:

    • Alkali eye burns can cause severe damage to ocular tissues.
    • Understanding the pH changes in aqueous humor is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the effect of sodium hydroxide and ammonium hydroxide on rabbit aqueous humor pH.
    • To evaluate the efficacy of paracentesis and intracameral phosphate buffer in managing alkali burns.

    Main Methods:

    • Application of varying concentrations and volumes of sodium hydroxide and ammonium hydroxide to rabbit corneas.
    • Monitoring of aqueous humor pH over time.
    • Assessment of pH changes following paracentesis and intracameral interventions.

    Main Results:

    • Sodium hydroxide and ammonium hydroxide caused rapid and significant increases in aqueous humor pH, reaching up to 12 and 10.8 respectively.
    • External lavage had minimal effect on pH reduction after sodium hydroxide burns.
    • Paracentesis alone significantly lowered pH, and intracameral phosphate buffer further reduced it.

    Conclusions:

    • Severe alkali burns necessitate prompt intervention.
    • Paracentesis combined with anterior chamber reformation using sterile solutions is a recommended treatment strategy for moderate to severe alkali eye injuries.

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