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Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
Published on: April 1, 2019
Topical diquafosol for patients with obstructive meibomian gland dysfunction
Reiko Arita1, Jun Suehiro, Tsuyoshi Haraguchi
1Department of Ophthalmology, Itoh Clinic, Minami-ku, Saitama, Japan. ritoh@za2.so-net.ne.jp
The British Journal of Ophthalmology
|April 16, 2013
Summary
Topical diquafosol effectively treated obstructive meibomian gland dysfunction (MGD). The treatment improved ocular symptoms, tear film, and meibomian gland morphology, confirmed by quantitative image analysis.
Area of Science:
- Ophthalmology
- Ocular Surface Disease
- Meibomian Gland Dysfunction
Background:
- Meibomian gland dysfunction (MGD) is a common cause of evaporative dry eye.
- Current treatments for MGD often focus on symptom relief rather than directly addressing gland morphology.
Purpose of the Study:
- To assess the efficacy of topical diquafosol in patients with obstructive MGD.
- To evaluate changes in tear film parameters and meibomian gland morphology using quantitative analysis.
Main Methods:
- 10 patients with obstructive MGD received 3% diquafosol ophthalmic solution four times daily.
- Ocular symptoms, lid margin abnormalities, meibomian gland structure (meiboscore), superficial punctate keratopathy (SPK), meibum quality, and tear production were assessed.
- Quantitative image analysis of meibomian glands was performed.
Main Results:
- Topical diquafosol therapy for over 4 months led to significant improvements.
- Ocular symptoms, lid abnormalities, SPK, and meibum grade decreased.
- Tear film break-up time, tear meniscus height, and meibomian gland area ratio significantly increased (p<0.0001).
Conclusions:
- Quantitative image analysis is a valuable tool for evaluating meibomian gland morphological changes.
- Topical diquafosol demonstrates effectiveness in treating obstructive MGD.
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