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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Related Experiment Video

Updated: May 12, 2026

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

Published on: October 2, 2017

Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors.

Luis N Marenco1, Gautam Bahl, Lorra Hyland

  • 1Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 16, 2013
PubMed
Summary

We introduce three integrated databases: the Olfactory Receptor Database (ORDB) for genomics and proteomics, OdorDB for odorant-receptor interactions, and OdorModelDB for computational olfactory receptor models. These resources enhance olfactory research data accessibility.

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Related Experiment Videos

Last Updated: May 12, 2026

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
09:11

Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay

Published on: October 2, 2017

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells
04:55

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Published on: February 23, 2011

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity
12:02

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

Area of Science:

  • Olfactory neuroscience
  • Bioinformatics
  • Computational chemistry

Background:

  • Olfactory receptors (ORs) and odorant molecules are crucial for smell perception.
  • Integrating diverse data types (genomics, proteomics, odorants, computational models) is challenging.
  • Existing resources for olfactory research are often fragmented.

Purpose of the Study:

  • To present three integrated databases: Olfactory Receptor Database (ORDB), OdorDB, and OdorModelDB.
  • To describe the SenseLab suite of databases and its integrated data.
  • To discuss the computational infrastructure supporting data management and integration.

Main Methods:

  • Data integration across multiple specialized databases.
  • Development of a unified computational infrastructure.
  • Implementation of automated data population from external sources.

Main Results:

  • ORDB provides genomics and proteomics data for ORs.
  • OdorDB links odorants to specific olfactory receptor interactions.
  • OdorModelDB offers computational models of ORs.
  • The SenseLab suite integrates these resources for comprehensive olfactory research.

Conclusions:

  • The integrated SenseLab databases (ORDB, OdorDB, OdorModelDB) provide a unified platform for olfactory research.
  • The computational infrastructure enhances data storage, retrieval, and dissemination.
  • Automated data population ensures up-to-date and comprehensive information for olfactory studies.