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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

Updated: May 12, 2026

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Vascular proteomics.

Maria G Barderas1, Fernando Vivanco, Gloria Alvarez-Llamas

  • 1Department of Vascular Physiopathology, SESCAM, Hospital Nacional de Parapléjicos, Toledo, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|April 16, 2013
PubMed
Summary
This summary is machine-generated.

Proteomics offers new insights into atherosclerosis, a major cause of death. Studying proteins in various biological samples helps identify early biomarkers for unstable plaques, crucial for preventing heart attack and stroke.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
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10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Cardiovascular pathology
  • Proteomics
  • Biomarker discovery

Background:

  • Cardiovascular diseases, particularly atherosclerosis, are leading causes of mortality in developed nations.
  • Atherosclerosis involves chronic inflammation and lipid accumulation in arteries, progressing from endothelial damage to advanced plaques.
  • Plaque rupture and thrombosis lead to acute events like myocardial infarction and stroke.

Purpose of the Study:

  • To provide an overview of recent advancements in proteomic studies of atherosclerosis.
  • To highlight the importance of identifying early biomarkers for plaque instability and rupture susceptibility.
  • To discuss proteomic approaches applied to various biological components relevant to atherosclerosis.

Main Methods:

  • Proteomic analyses of vascular tissues, artery layers, and cells (proteomes and secretomes).
  • Investigation of plasma/serum, exosomes, lipoproteins, and metabolites using proteomic techniques.
  • Review of latest findings from proteomic studies focused on atherosclerosis and related vascular diseases.

Main Results:

  • Proteomics has been successfully applied to study proteins involved in atherosclerotic pathological processes.
  • Studies have explored diverse biological elements, including tissues, cells, and biofluids.
  • Advances in proteomics enable a deeper understanding of the molecular mechanisms underlying atherosclerosis.

Conclusions:

  • Proteomic research is vital for understanding atherosclerosis and identifying potential therapeutic targets.
  • Early detection of plaque instability through proteomic biomarkers can aid in preventing acute cardiovascular events.
  • Continued proteomic investigations promise significant contributions to managing cardiovascular diseases.