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Updated: May 12, 2026

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Vascular proteomics

Maria G Barderas1, Fernando Vivanco, Gloria Alvarez-Llamas

  • 1Department of Vascular Physiopathology, SESCAM, Hospital Nacional de Parapléjicos, Toledo, Spain.

Methods in Molecular Biology (Clifton, N.J.)
|April 16, 2013
PubMed

Insights

Proteomics offers new insights into atherosclerosis, a major cause of death. Studying proteins in various biological samples helps identify early biomarkers for unstable plaques, crucial for preventing heart attack and stroke.

Area of Science:

  • Cardiovascular pathology
  • Proteomics
  • Biomarker discovery

Background:

  • Cardiovascular diseases, particularly atherosclerosis, are leading causes of mortality in developed nations.
  • Atherosclerosis involves chronic inflammation and lipid accumulation in arteries, progressing from endothelial damage to advanced plaques.
  • Plaque rupture and thrombosis lead to acute events like myocardial infarction and stroke.

Purpose of the Study:

  • To provide an overview of recent advancements in proteomic studies of atherosclerosis.
  • To highlight the importance of identifying early biomarkers for plaque instability and rupture susceptibility.
  • To discuss proteomic approaches applied to various biological components relevant to atherosclerosis.

Main Methods:

  • Proteomic analyses of vascular tissues, artery layers, and cells (proteomes and secretomes).
  • Investigation of plasma/serum, exosomes, lipoproteins, and metabolites using proteomic techniques.
  • Review of latest findings from proteomic studies focused on atherosclerosis and related vascular diseases.

Main Results:

  • Proteomics has been successfully applied to study proteins involved in atherosclerotic pathological processes.
  • Studies have explored diverse biological elements, including tissues, cells, and biofluids.
  • Advances in proteomics enable a deeper understanding of the molecular mechanisms underlying atherosclerosis.

Conclusions:

  • Proteomic research is vital for understanding atherosclerosis and identifying potential therapeutic targets.
  • Early detection of plaque instability through proteomic biomarkers can aid in preventing acute cardiovascular events.
  • Continued proteomic investigations promise significant contributions to managing cardiovascular diseases.

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