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Updated: May 12, 2026

Rapid Whole-Mount High-Resolution Imaging of Small Animal Vasculature for Quantitative Studies
Published on: May 23, 2025
Use of TOF-SIMS in vascular biology
Sebastián Mas1, Raúl Pérez, Jesús Egido
1Vascular Research Lab IIS-Fundación Jiménez Díaz, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain.
Abstract:
Secondary ion mass spectrometry is a technique used for surface analysis. The recent introduction of metal cluster ionization sources opened the possibility to probe biological tissues, due to its reduced in-source fragmentation. Despite its limitations in mass range of the molecules analyzed, a combination of minimal sample processing, sensibility, and unsurpassed lateral resolution makes TOF-SIMS a good tool for molecular imaging in pathology.

