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Updated: May 12, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Aggressive giant cell reparative granuloma of the nasal cavity
Hajime Ishinaga1, Kazuya Otsu, Genshin Mouri
1Department of Otorhinolaryngology-Head & Neck Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Mie, Tsu 514-8507, Japan.
Abstract:
Giant cell reparative granuloma (GCRG) is an uncommon and nonneoplastic reactive tumor that involves the maxilla and mandible in the region of the head and neck. It is rare in the nasal cavity, and it might be misdiagnosed. We reported a very aggressive GCRG with intracranial invasion, which was treated surgically via a combined approach of a lateral rhinotomy with a craniotomy by bilateral coronal incision. The pathology was consistent with GCRG. A short literature review about diagnosis, clinical behavior, and treatment of this tumor entity is given.
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