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Related Experiment Videos

Effect of ascorbic acid on plasma alcohol clearance.

M F Chen1, H W Boyce, J M Hsu

  • 1Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612.

Journal of the American College of Nutrition
|June 1, 1990
PubMed
Summary

Ascorbic acid (vitamin C) supplements significantly improve how quickly the body processes alcohol. Both short-term and long-term vitamin C intake enhance alcohol clearance from the plasma.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Human Physiology

Background:

  • Alcohol metabolism is a critical area of human physiology.
  • Ascorbic acid (vitamin C) is an essential nutrient with antioxidant properties.
  • Understanding factors that influence alcohol clearance is important for public health.

Purpose of the Study:

  • To investigate the impact of ascorbic acid supplementation on plasma alcohol clearance.
  • To compare the effects of short-term versus long-term ascorbic acid pretreatment.
  • To assess the influence of different alcohol dosages on these parameters.

Main Methods:

  • 13 healthy male subjects participated in the study.
  • Alcohol was administered at 0.5 g/kg and 0.8 g/kg body weight.

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  • Plasma alcohol, ascorbic acid, red-cell reduced glutathione, and plasma alanine aminotransferase were measured over 6 hours.

    • Main Results:

    • Ascorbic acid pretreatment, both short-term and long-term, significantly enhanced plasma alcohol clearance at both alcohol dosages.
    • Long-term ascorbic acid pretreatment showed a trend towards better alcohol clearance, but the difference was not statistically significant compared to short-term.
    • Alcohol dosage and ascorbic acid levels did not significantly affect red-cell reduced glutathione or plasma alanine aminotransferase activity.

    Conclusions:

    • Ascorbic acid supplementation is effective in accelerating plasma alcohol clearance.
    • Both short-term and long-term vitamin C intake can benefit alcohol metabolism.
    • Further research may explore optimal ascorbic acid dosages and durations for alcohol clearance enhancement.