Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Sociodemographic Variation of Allergic Diseases in Australia: Findings From the Australian National Health Survey.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis.

The World Allergy Organization journal·2026
Same author

Non-injectable versus injectable epinephrine treatment thresholds for acute allergic reactions in the community.

The journal of allergy and clinical immunology. In practice·2026
Same author

Epinephrine and emergency medical services activation recommendations during acute allergic reactions in community settings: International consensus report.

The Journal of allergy and clinical immunology·2025
Same author

Effects of Butyrylated High Amylose Maize Starch (HAMSB) as an Adjuvant for Oral Immunotherapy.

Allergy·2025
Same author

Nuts For Babies Study: protocol for a randomised controlled trial in Australia investigating if the risk of developing peanut and cashew nut allergies during infancy can be reduced by a high peanut and cashew nut maternal diet for the first 6 months of lactation.

BMJ open·2025
Same journal

Effectiveness of Therapeutic and Educational Interventions for Childhood Separation Anxiety: A Scoping Review.

Journal of paediatrics and child health·2026
Same journal

Impact of Access to Pasteurised Donor Human Milk on Rates of Necrotising Enterocolitis in Neonatal Units in Australia: A Cohort Study.

Journal of paediatrics and child health·2026
Same journal

Prescribing Cascade in Children With Chronic Complex Diseases: An Argument for De-Escalation and Medication Review, a Case Report.

Journal of paediatrics and child health·2026
Same journal

Post-COVID-19 Autonomic Dysfunction in an Adolescent: Ogilvie Syndrome With Acute Urinary Retention.

Journal of paediatrics and child health·2026
Same journal

Serial Ultrasonography-Guided Management of Primary Sternal Osteomyelitis With Abscess Formation in a Child: A Case Report.

Journal of paediatrics and child health·2026
Same journal

"Raccoon Eyes": A Rare Presentation of Paediatric Scrub Typhus.

Journal of paediatrics and child health·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Insect allergy in children.

John W Tan1, Dianne E Campbell

  • 1Department of Allergy and Immunology, Children's Hospital Westmead; Discipline of Paediatric and Child Health, University of Sydney, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

Insect stings can cause allergic reactions, ranging from local swelling to life-threatening anaphylaxis. Venom immunotherapy is recommended only for children experiencing systemic reactions, not large local ones.

Keywords:
anaphylaxisimmunotherapyinsect allergy

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Related Experiment Videos

Last Updated: May 12, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Area of Science:

  • Allergy and Immunology
  • Pediatric Allergy
  • Toxicology

Background:

  • Allergic reactions to insect bites and stings are frequent, with presentations varying from localized responses to anaphylaxis.
  • In pediatric populations, large local reactions are the most common manifestation of insect stings.
  • Hymenoptera insects (bees, wasps, ants) are primary culprits for insect-induced anaphylaxis, though fewer allergic children experience this compared to adults.

Purpose of the Study:

  • To review the presentation and management of allergic reactions to insect stings in children.
  • To differentiate between local and systemic reactions and their implications for treatment.
  • To clarify the indications for venom immunotherapy in pediatric patients.

Main Methods:

  • Clinical review of allergic reactions to insect stings in children.
  • Emphasis on diagnostic importance of patient history over laboratory tests.
  • Evaluation of treatment strategies, including venom immunotherapy.

Main Results:

  • Large local reactions are the most common presentation in children.
  • Diagnosis of anaphylaxis relies heavily on clinical history due to unreliable laboratory tests.
  • Venom immunotherapy is effective but indicated only for systemic reactions, not large local reactions.

Conclusions:

  • Venom immunotherapy is not necessary for children with large local reactions to insect stings.
  • Management decisions should be guided by reaction severity and clinical history.
  • Further research may refine diagnostic and therapeutic approaches for pediatric insect sting allergies.