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Related Experiment Video

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Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors
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Paper-based SlipPAD for high-throughput chemical sensing.

Hong Liu, Xiang Li, Richard M Crooks

    Analytical Chemistry
    |April 17, 2013
    PubMed
    Summary

    We developed a novel paper analytical device (PAD) called SlipPAD for high-throughput, multiplexed sensing. This simple, paper-based system enables robust chemical analysis using colorimetric and fluorescent assays.

    Area of Science:

    • Analytical Chemistry
    • Biotechnology
    • Materials Science

    Background:

    • Paper analytical devices (PADs) offer low-cost, portable sensing solutions.
    • The SlipChip concept enables complex microfluidic operations on simple platforms.
    • Integrating these concepts can enhance PAD capabilities for advanced assays.

    Discussion:

    • The SlipPAD utilizes two wax-patterned paper layers that slide relative to each other.
    • This design allows for simultaneous or sequential fluid manipulation across numerous sensing sites.
    • The device maintains the simplicity of paper-based assays while enabling high-throughput and multiplexing.

    Key Insights:

    • Demonstrated robust, high-throughput, multiplexed sensing using a novel SlipChip-based PAD.
    • Successfully performed both homogeneous and heterogeneous assays via controlled fluid flow.

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  • Validated the device's applicability using colorimetric and fluorescent chemical analyses.

    • Outlook:

    • Potential for widespread use in point-of-care diagnostics and environmental monitoring.
    • Further development could expand assay types and sensitivity.
    • The SlipPAD platform offers a scalable solution for complex microfluidic applications on paper.