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Glucose tolerance test in leprosy.

R Garg1, J K Agrawal, H S Bajpai

  • 1Division of Endocrinology Institute, Medical Science B.H.U., Varanasi.

Indian Journal of Leprosy
|January 1, 1990
PubMed
Summary
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Leprosy affects glucose tolerance, with abnormal glucose tolerance test (GTT) results common in lepromatous leprosy and lepra reactions. Disease duration also influences GTT outcomes, indicating a link between leprosy progression and glucose metabolism.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Leprosy, a chronic infectious disease, can impact various bodily systems.
  • Understanding metabolic alterations in leprosy is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate glucose tolerance patterns in patients with different forms of leprosy.
  • To correlate glucose tolerance test (GTT) results with leprosy type, lepra reaction, and disease duration.

Main Methods:

  • A glucose tolerance test (GTT) was performed on 43 leprosy patients.
  • Patients were categorized by leprosy type (tuberculoid, borderline, lepromatous) and presence of lepra reaction.
  • GTT results were analyzed in relation to disease duration.

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Main Results:

  • Normal GTT curves were frequent in tuberculoid leprosy.
  • Flat GTT curves were observed in borderline and lepromatous leprosy.
  • Diabetic GTT curves were common during lepra reactions.
  • Fasting blood sugar was low in lepromatous leprosy and slightly elevated in lepra reactions.
  • Disease duration correlated with GTT patterns: normal in 0-6 months, flat in 7-12 months, and diabetic in over 2 years.

Conclusions:

  • Leprosy significantly influences glucose tolerance, with distinct patterns observed across different clinical forms and stages.
  • Lepra reactions and longer disease duration are associated with more pronounced glucose metabolism disturbances, including diabetic GTT curves.