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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

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Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles
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Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles

Published on: May 20, 2024

GigaDB: announcing the GigaScience database.

Tam P Sneddon1, Peter Li, Scott C Edmunds

  • 1GigaScience, BGI-Hong Kong Co, Ltd, 16 Dai Fu Street, Tai Po Industrial Estate, NT, Hong Kong. scott@gigasciencejournal.com.

Gigascience
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

GigaDB is a database supporting the GigaScience journal, enhancing research reproducibility and open data sharing. It provides a repository for data and tools when no other public option is available.

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Area of Science:

  • Life sciences
  • Biomedical research
  • Genomics

Background:

  • The GigaScience journal aims to promote open data and research reproducibility.
  • There is a need for integrated platforms that link publications with supporting data and tools.
  • Existing public repositories may not always be suitable for all types of research data.

Purpose of the Study:

  • To introduce and describe the GigaDB database.
  • To explain how GigaDB supports the goals of GigaScience.
  • To highlight GigaDB's role in data and tool archiving.

Main Methods:

  • GigaDB is designed as an accompanying database for GigaScience.
  • It facilitates the integration of manuscript publication with data and tools.
  • It serves as a repository for research outputs.

Main Results:

  • GigaDB enables seamless linking of research articles with their supporting data.
  • It provides a centralized location for data and tools, improving accessibility.
  • The database supports the journal's commitment to open science principles.

Conclusions:

  • GigaDB is a valuable resource for researchers, promoting data sharing and reproducibility.
  • It addresses the need for dedicated repositories for scientific data and tools.
  • GigaDB strengthens the GigaScience ecosystem by ensuring data availability and reuse.