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Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...

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Related Experiment Video

Updated: May 12, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Right ventricular function in left ventricular disease: pathophysiology and implications.

Konstantin Schwarz1, Satnam Singh, Dana Dawson

  • 1University of Aberdeen, Aberdeen, United Kingdom.

Heart, Lung & Circulation
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

Left and right ventricle function are linked. Left ventricular contraction aids right ventricular function, especially when right ventricular afterload is high. Impaired left ventricular function reduces this interaction, leading to right ventricular failure.

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Last Updated: May 12, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

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Published on: February 1, 2022

Area of Science:

  • Cardiology
  • Physiology
  • Biomedical Engineering

Background:

  • The left and right ventricles (LV and RV) have interconnected functions due to shared muscle fibers in the interventricular septum.
  • Left ventricular (LV) contraction normally augments right ventricular (RV) contraction via systolic ventricular interaction.

Purpose of the Study:

  • To elucidate the mechanisms by which left ventricular dysfunction impacts right ventricular contractile performance.
  • To describe the phenomenon of systolic and diastolic ventricular interaction and its clinical implications.

Main Methods:

  • The study is primarily a conceptual and mechanistic review, synthesizing existing knowledge on ventricular mechanics.
  • It analyzes the impact of altered loading conditions and ventricular geometry on myocardial fiber function.

Main Results:

  • Increased RV afterload enhances dependence on systolic ventricular interaction, as oblique septal fibers are more efficient.
  • LV systolic dysfunction increases pulmonary artery pressure, reducing systolic ventricular interaction and impairing RV function.
  • Progressive LV spherical remodeling and RV enlargement can lead to diastolic constraint and clinical RV failure.

Conclusions:

  • Systolic ventricular interaction is crucial for RV function, particularly under increased afterload.
  • LV systolic dysfunction can precipitate RV failure through reduced interaction and diastolic constraint.
  • Understanding these interactions is vital for managing heart failure patients with combined ventricular dysfunction.