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Updated: May 12, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

[Myelodysplastic syndrome classification].

Ines Ghariani¹, Najia Braham, Mohsen Hassine

¹Laboratoire d'hématologie, CHU Farhat Hached, Sousse, Tunisia. gharianiines@gmail.com

Annales De Biologie Clinique

|April 17, 2013

Summary

Myelodysplastic syndromes (MDS) are myeloid disorders. Classifications evolved from FAB-1982 to WHO 2008, incorporating morphology, cytogenetics, and molecular biology for better diagnosis.

Keywords:

2001 WHO classification 2008 WHO classification FAB classification myelodysplastic syndrome

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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

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Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

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Published on: November 10, 2023

Area of Science:

Hematology
Oncology
Pathology

Background:

Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms.
The French-American-British (FAB) classification (1982) categorized MDS based on morphology and blast counts.
Previous classifications relied on morphological criteria and blast percentages.

Purpose of the Study:

To outline the evolution of MDS classification systems.
To detail the criteria used in the FAB and WHO classifications.
To highlight the advancements in MDS subtyping.

Main Methods:

Review of historical and current classification systems for MDS.
Comparison of diagnostic criteria between FAB (1982) and WHO (2001, 2008) classifications.
Identification of key parameters including morphology, blast counts, cytogenetics, and molecular markers.

Main Results:

The FAB classification used blast percentage, ringed sideroblasts, and monocyte counts.
The WHO classifications (2001, 2008) integrated cytogenetic and molecular data.
WHO-2008 considers peripheral cytopenia, blasts, ringed sideroblasts, Auer Rods, and cytogenetic abnormalities like 5q deletion.

Conclusions:

The WHO 2008 classification provides a more comprehensive approach to MDS diagnosis.
Integration of cytogenetic and molecular data refines MDS subtyping.
Updated classifications improve the definition of MDS subgroups such as refractory cytopenia and refractory anemia with excess blasts.