Related Experiment Video
Updated: May 12, 2026

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
Published on: June 28, 2024
[RBCs inclusions after splenectomy: not only Howell-Jolly bodies!]
Morgane Solis1, Julien Perrin, Jean-Claude Guédenet
1Service d'hématologie biologique, Pôle laboratoires, CHU de Nancy, France.
Abstract:
We report on several abnormalities of the red blood cells, in particular erythrocytic inclusions, in a 49 year old man. The blood smear presented with marked anisocytosis, target cells, acanthocytes and Howell-Jolly bodies, as well as Pappenheimer bodies and basophilic stippling. These abnormalities can be explained by the clinical context which associated splenectomy, iron overload and severe denutrition. The patient died a few weeks after from kidney and liver insufficiency. We comment on the different features of erythrocytic inclusions and the clinical situations in which they can be found.
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