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Related Concept Videos

Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
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Methods of Sterilization II: Chemical Methods

In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements.
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Methods of Sterilization I: Physical Methods01:29

Methods of Sterilization I: Physical Methods

As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
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Acid–Base Titration: Overview01:26

Acid–Base Titration: Overview

An acid-base titration is a technique used to determine the concentration of an unknown acid or base, using a titrant of known concentration–either a base for acid titration or an acid for base titration. The process involves gradually adding the titrant, leading to a predictable change in the pH of the solution. This change is plotted on a titration curve, showing how a solution's pH varies with the amount of titrant added. Such curves are instrumental in monitoring the titration's progress...
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Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Journal de chirurgie·1996
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Albumin priming enables safe and effective red blood cell exchange in low-weight children with sickle cell disease.

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Catastrophic CD34+ autologous hematopoietic stem cell collection despite sustained mobilization and solutions to rescue the harvests.

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Title of the study: Corrected Count Increment as a Predictor of Early Graft Dysfunction and Mortality Following Living Donor Liver Transplantation.

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Updated: May 12, 2026

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
05:34

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

[Laboratory accreditation: a long and useful process].

A Mercadier1

  • 1EFS Île-de-France, site transfusionnel Pitié-Salpêtrière, hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France. anne.mercadier@efs.sante.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

Official accreditation is now mandatory for French medical biology laboratories, ensuring reliable testing and quality services for patients. This accreditation by Cofrac acknowledges a laboratory's capability to perform medico-technical acts according to established standards.

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Area of Science:

  • Medical Laboratory Science
  • Quality Management Systems
  • Regulatory Compliance

Context:

  • France mandates official accreditation for all medical biology laboratories following a January 13, 2010 order.
  • The French Committee for Accreditation (Cofrac) is the sole authority responsible for delivering this accreditation.
  • Accreditation signifies a laboratory's validated ability to conduct medico-technical procedures within its defined scope.

Purpose:

  • To outline the requirements and significance of official accreditation for medical biology laboratories in France.
  • To emphasize the role of accreditation in ensuring the reliability of medical biology tests and the quality of patient services.
  • To detail the standards and documents laboratories must adhere to for accreditation.

Summary:

  • Medical biology laboratories in France require official accreditation from Cofrac, effective from January 13, 2010.
  • Accreditation confirms a laboratory's competence in performing medico-technical acts, adhering to Standard 15189, Cofrac documents (SH REF 02), and regulatory rules.
  • While initially demanding, accreditation is ultimately viewed by personnel as recognition of their quality and efficiency.

Impact:

  • Enhances the reliability and quality of medical biology testing services for patient benefit.
  • Establishes a standardized benchmark for laboratory performance and operational excellence.
  • Provides a framework for continuous improvement and professional recognition within the medical biology sector.