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Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Peripheral Artery Disease IV: Nursing Management

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

Peripheral Artery Disease V: Postoperative Nursing Management

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Related Experiment Video

Updated: May 12, 2026

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

[Genic and cellular therapy for peripheral arterial diseases].

D Smadja¹, J-S Silvestre, B I Lévy

¹Inserm U 765, service d'hématologie biologique, hôpital européen Georges-Pompidou, faculté de pharmacie, université Paris-Descartes, 75006 Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine

|April 17, 2013

Summary

Critical limb ischemia, a severe peripheral arterial disease complication, has limited treatment options. Gene and cell therapies show promise for improving lower-limb blood flow, but face challenges with efficacy and safety.

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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Area of Science:

Vascular Biology and Regenerative Medicine
Gene Therapy
Cell Therapy

Context:

Peripheral arterial disease (PAD) can progress to critical limb ischemia (CLI), particularly in diabetic patients, presenting limited therapeutic options.
CLI significantly impacts lower-limb perfusion, necessitating innovative treatment strategies.
Gene and cellular therapies are emerging as potential interventions for CLI.

Purpose:

To review the clinical trials of gene therapy for CLI, noting reasons for abandonment such as adverse effects and limited efficacy.
To discuss various stem cell types (endothelial progenitor cells, mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells) used in cell therapy for CLI.
To highlight challenges in stem cell characterization and report outcomes from key clinical trials.

Summary:

Gene therapy trials for CLI have largely been discontinued due to significant side effects, modest therapeutic effects, and major risks.
Cellular therapies utilize diverse stem cell types, including endothelial progenitor cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells.
Clinical trials in cell therapy for CLI face hurdles related to stem cell characterization and have yielded varied results.

Impact:

Gene therapy for CLI has demonstrated significant safety and efficacy concerns, leading to trial abandonment.
Cellular therapies offer a promising alternative for CLI, with ongoing research into optimizing stem cell types and delivery methods.
Further research is crucial to overcome characterization challenges and improve the clinical outcomes of cell-based therapies for critical limb ischemia.