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Updated: May 12, 2026

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
Stepwise regulation of hole transport in DNA by control of triplex formation
Ken-ichi Haruna1, Haruka Iida, Sei-ichi Nishimoto
1Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
Abstract:
A functionality for regulating hole transport efficiency is a prerequisite for the utilization of DNA duplexes as nanodevices. Herein, we report the regulation of hole transport in anthraquinone-tethered DNA with dual triplex forming sites. Long-range photooxidation experiments showed that hole transport was effectively suppressed by the formation of triplex at low temperature, while it was recovered by dissociation to the duplex at higher temperature. Variation of temperature induced the formation and dissociation of the third strand at each triplex region individually, leading to the stepwise regulation of hole transport in DNA.
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