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Published on: September 22, 2019
Neutrophilic dermatoses and inflammatory bowel diseases
A V Marzano1, C Menicanti, C Crosti
1Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Italy. angelovalerio.marzano@policlinico.mi.it
Summary
Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are neutrophilic dermatoses often linked to inflammatory bowel diseases (IBD). This review covers PG, SS, and aseptic abscesses syndrome, highlighting their neutrophilic origins and IBD associations.
Area of Science:
- Dermatology
- Immunology
- Gastroenterology
Background:
- Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are neutrophilic dermatoses characterized by neutrophil accumulation in the skin.
- These conditions are increasingly recognized as autoinflammatory diseases linked to innate immune dysregulation.
- Both PG and SS frequently co-occur with inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease.
Purpose of the Study:
- To review the key features of pyoderma gangrenosum (PG) and Sweet's Syndrome (SS).
- To discuss their classification within neutrophilic dermatoses (ND) and autoinflammatory diseases.
- To explore the association between ND and inflammatory bowel diseases (IBD), including aseptic abscesses syndrome.
Main Methods:
- Literature review focusing on pyoderma gangrenosum (PG) and Sweet's Syndrome (SS).
- Analysis of disease characteristics, pathogenesis, and associations with inflammatory bowel diseases (IBD).
- Inclusion of aseptic abscesses syndrome as a related entity within neutrophilic dermatoses (ND).
Main Results:
- PG presents as painful ulcers, while SS is characterized by fever and neutrophilic skin lesions.
- Aseptic abscesses syndrome, a newly described entity, involves splenic and cutaneous abscesses and can mimic PG and SS.
- Neutrophilic dermatoses (ND) show a significant association with inflammatory bowel diseases (IBD).
Conclusions:
- Pyoderma gangrenosum (PG), Sweet's Syndrome (SS), and aseptic abscesses syndrome are distinct but related neutrophilic dermatoses (ND).
- These conditions share links with autoinflammation and inflammatory bowel diseases (IBD).
- Understanding these associations is crucial for comprehensive patient management.
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