Related Experiment Video
Updated: May 12, 2026

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Published on: August 6, 2013
Biomarkers for smoking cessation
K J Bough1, C Lerman, J E Rose
1Division of Pharmacotherapies and Medical Consequences, National Institute on Drug Abuse, Bethesda, Maryland, USA. boughk@mail.nih.gov
This review explores biomarkers for smoking cessation, including diagnostic, pharmacodynamic, and predictive types. These tools can improve treatment personalization and accelerate drug development for smoking cessation therapies.
Area of Science:
- Biomarkers in therapeutic development
- Pharmacology and drug discovery
- Addiction research
Background:
- Therapeutic development relies on evaluative tools like biomarkers.
- Biomarkers aid in disease diagnosis, treatment personalization, and drug discovery.
- Smoking cessation therapies benefit from precise evaluative measures.
Purpose of the Study:
- To review diagnostic, pharmacodynamic, and predictive biomarkers for smoking cessation.
- To highlight the role of biomarkers in enhancing drug development efficiency.
- To present a comprehensive overview of current and emerging biomarkers in smoking cessation.
Main Methods:
- Literature review of existing research on smoking cessation biomarkers.
- Categorization of biomarkers by function (diagnostic, pharmacodynamic, predictive).
- Exploration of diverse approaches including metabolism, genetics, and neuroimaging.
Main Results:
- Identification of promising biomarkers across various domains.
- Discussion of preclinical, analytical, and regulatory considerations for biomarker qualification.
- Synthesis of current knowledge on biomarkers supporting smoking cessation.
Conclusions:
- Biomarkers are crucial for advancing smoking cessation treatment.
- Metabolism, genetics, and neuroimaging offer key avenues for biomarker discovery.
- A clear pathway toward biomarker qualification is essential for clinical translation.
Related Concept Videos
Statistical Methods for Analyzing Epidemiological Data
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Drug Dependence
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
