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In vitro methods to support transporter evaluation in drug discovery and development

K L R Brouwer1, D Keppler, K A Hoffmaster

  • 1Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. kbrouwer@unc.edu

Clinical Pharmacology and Therapeutics
|April 17, 2013
PubMed
Summary

This white paper reviews methods for assessing drug transporter roles in human drug disposition. It highlights in vitro tools and their use in predicting drug-drug interactions (DDIs) and understanding drug metabolism.

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