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Published on: October 27, 2014
Brentuximab vedotin (SGN-35) in a 3-year-old child with relapsed systemic anaplastic large cell lymphoma
Bethany Mikles1, Jennifer Levine, Tatyana Gindin
1*Division of Pediatric Hematology/Oncology, Naval Medical Center Portsmouth, Portsmouth, VA Departments of †Pediatric Oncology/Blood and Marrow Transplant ‡Pathology, Columbia University Medical Center, NY Presbyterian Hospital, New York, NY.
Abstract:
The treatment of anaplastic large cell lymphoma (ALCL) has largely relied on anthracycline-based chemotherapy. Targeted lymphoma therapy, using an anti-CD30 antibody, provides an innovative treatment modality for specific lymphomas, particularly ALCL. Brentuximab vedotin (BV; SGN-35) uses a CD30 monoclonal antibody to generate apoptosis of targeted lymphoma cells. We present a pediatric patient with ALCL who experienced second relapse after standard chemotherapy and autologous and allogeneic hematopoietic stem cell transplantation. This patient has been treated with BV as a single agent and has sustained remission for several months. BV offers a targeted treatment for relapsed ALCL, even after multiple relapses.