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Related Experiment Video

Updated: May 12, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Published on: October 16, 2013

Colonic perineuriomas with and without crypt serration: a comparative study.

Gabriel M Groisman¹, Dov Hershkovitz, Michael Vieth

¹The Institute of Pathology, Hillel Yaffe Medical Center, Hadera, Israel. groisman@hy.health.gov.il

The American Journal of Surgical Pathology

|April 17, 2013

Summary

This summary is machine-generated.

Colorectal perineuriomas with serrated crypts often have BRAF mutations, while those without serration do not. This suggests these polyps may be variants of a single lesion.

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Published on: August 1, 2025

Area of Science:

Gastroenterology
Gastrointestinal Pathology
Molecular Pathology

Background:

Colorectal perineuriomas are benign polyps with distinct histological features.
Previous research linked BRAF mutations to serrated perineuriomas, questioning the nature of non-serrated types.
A gap existed in comparative studies of serrated versus non-serrated perineuriomas.

Purpose of the Study:

To compare clinical, histological, immunohistochemical, and molecular characteristics of serrated (SPs) and non-serrated perineuriomas (NSPs).
To investigate the presence and significance of BRAF mutations in both types of colorectal perineuriomas.

Main Methods:

Retrospective analysis of 15 NSPs and 45 SPs.
Evaluation of clinical, histological, and immunohistochemical features (using perineurial markers).
Molecular analysis for BRAF mutations in a subset of cases.

Main Results:

No significant clinical or histological differences were observed between SPs and NSPs, apart from crypt architecture.
All lesions expressed perineurial markers.
BRAF mutations were identified in 62% of SPs but in none of the NSPs (p=0.004).

Conclusions:

BRAF mutations are associated with the serrated epithelium of SPs.
SPs and NSPs share similar clinical and stromal features, suggesting they may be variants of a single entity.
The absence of BRAF mutations in NSPs supports a distinct molecular origin or pathway.