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Triglyceride-to-HDL cholesterol ratio. Predictive value for CHD severity and new-onset heart failure

Z Yunke1, L Guoping, C Zhenyue

  • 1Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, Ruijin 2nd Road, Shanghai, China.

Herz
|April 17, 2013
PubMed

Insights

The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio predicts coronary heart disease (CHD) severity. Higher TG/HDL-C ratios are linked to more severe CHD and predict heart failure in patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable biomarkers for CHD severity and prognosis is crucial for patient management.
  • The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio is a lipid-based index that warrants further investigation in CHD.

Purpose of the Study:

  • To investigate the association between the TG/HDL-C ratio and the severity of coronary heart disease (CHD).
  • To evaluate the TG/HDL-C ratio's predictive value for in-hospital CHD events, including new-onset heart failure.
  • To assess the TG/HDL-C ratio's role in the long-term prognosis of CHD patients.

Main Methods:

  • A cohort of 317 patients underwent coronary angiography, divided into a CHD group (n=233) and a control group (n=84).
  • The TG/HDL-C ratio was calculated at baseline for all participants.
  • CHD severity was quantified using the Gensini score, and correlations with the TG/HDL-C ratio were analyzed.

Main Results:

  • Patients with CHD exhibited significantly higher TG/HDL-C ratios compared to controls (P < 0.001).
  • A positive correlation was observed between the TG/HDL-C ratio and the Gensini score, indicating increased CHD severity.
  • Elevated TG/HDL-C ratios were associated with new-onset heart failure and adverse events during a 3-year follow-up (P < 0.05 and P < 0.01, respectively).

Conclusions:

  • The TG/HDL-C ratio serves as a valuable predictor of coronary heart disease severity.
  • This lipid ratio can aid in identifying CHD patients at higher risk for in-hospital new-onset heart failure.
  • The TG/HDL-C ratio demonstrates potential as a prognostic marker in the management of coronary heart disease.
Abstract

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