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CCR5 Δ 32 mutation is not prevalent in Iranians with chronic HBV infection

Hossein Khorramdelazad1, Elham Hakimizadeh, Gholamhossein Hassanshahi

  • 1Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Journal of Medical Virology
|April 17, 2013
PubMed

Insights

The CCR5 delta 32 mutation was not found in chronic Hepatitis B virus (HBV) patients in Southeast Iran. This suggests no significant link between this CCR5 gene mutation and HBV infection persistence in this population.

Area of Science:

  • Immunology
  • Genetics
  • Hepatology

Background:

  • Chemokine receptor CCR5 is crucial for recruiting antiviral immune cells to the liver.
  • The CCR5 delta 32 mutation inactivates the receptor, with debated roles in Hepatitis B virus (HBV) infection outcomes.
  • Understanding CCR5 delta 32 prevalence in HBV is vital for clarifying its role in infection persistence.

Purpose of the Study:

  • To compare the frequency of the CCR5 delta 32 mutation in chronically HBV-infected patients versus healthy individuals in Southeast Iran.
  • To investigate the potential association between CCR5 delta 32 and HBV infection status.

Main Methods:

  • A case-control study involving 60 chronic HBV patients and 300 healthy controls from Southeast Iran.
  • Gap-PCR technique used to detect the presence of the CCR5 delta 32 mutation in both groups.

Main Results:

  • None of the 60 chronic HBV patients possessed the CCR5 delta 32 mutation.
  • A low frequency (1%) of heterozygosity for CCR5 delta 32 was observed in the healthy control group (3 out of 300).

Conclusions:

  • The CCR5 delta 32 mutation is not prevalent in chronically HBV-infected individuals or healthy controls in Southeast Iran.
  • The findings suggest a lack of significant correlation between CCR5 delta 32 and HBV pathogenicity in this specific population.
  • Genetic variations within the population may influence the prevalence and impact of the CCR5 delta 32 mutation.

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