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Updated: May 12, 2026
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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
[Isolated gonadotropic deficiency after multiple concussions in a professional soccer player]
M Auer1, G K Stalla, A P Athanasoulia
1Abteilung für Innere Medizin, Endokrinologie und Diabetes, Max-Planck-Institut für Psychiatrie, München. mauer@mpipsykl.mpg.de
Deutsche Medizinische Wochenschrift (1946)
|April 17, 2013
Summary
Repeated mild head trauma in athletes can cause pituitary dysfunction, leading to hormonal imbalances like low testosterone. Early diagnosis and treatment, such as testosterone substitution, can effectively manage these symptoms.
Area of Science:
- Neuroendocrinology
- Sports Medicine
Background:
- Professional athletes, particularly in contact sports like soccer, are susceptible to repeated mild head trauma.
- Such trauma, even without loss of consciousness, can lead to significant health issues.
Observation:
- A 27-year-old professional soccer player presented with loss of libido, erectile dysfunction, and fatigue.
- Investigations revealed low testosterone and luteinizing hormone levels, but pituitary function was otherwise intact.
Findings:
- The patient's symptoms were attributed to pituitary deficiency secondary to cumulative head trauma from soccer.
- Testosterone substitution therapy led to significant symptom regression within four months.
Implications:
- Mild, repetitive head trauma in athletes should be considered a potential cause of isolated pituitary dysfunction.
- This highlights the importance of recognizing and managing hormonal imbalances in athletes, even after sub-concussive injuries.
