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Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer
Shuichiro Kobayashi1, Fumitaka Koga, Kohei Kajino
1Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Journal of Magnetic Resonance Imaging : JMRI
|April 17, 2013
Summary
Apparent diffusion coefficient (ADC) value in bladder cancer correlates with tumor aggressiveness. Lower ADC values indicate higher Ki-67 labeling index (LI) and advanced T stage, suggesting increased invasiveness and proliferation.
Area of Science:
- Oncology
- Radiology
- Biomarker Research
Background:
- Bladder cancer diagnosis and staging rely on traditional methods.
- Identifying reliable biomarkers for bladder cancer aggressiveness is crucial for treatment planning.
Purpose of the Study:
- To evaluate the apparent diffusion coefficient (ADC) value as a potential biomarker for bladder cancer.
- To investigate the association between ADC value, Ki-67 labeling index (LI), and clinicopathological prognosticators.
Main Methods:
- Diffusion-weighted MRI (DW-MRI) was performed on 132 bladder cancer patients before surgery.
- ADC values of index tumors were measured and correlated with Ki-67 LI and other prognostic factors.
Main Results:
- ADC values were significantly lower in tumors with higher Ki-67 LI, sessile morphology, larger size, higher grade, and advanced T stage.
- A strong inverse correlation was observed between ADC value and Ki-67 LI (ρ = -0.57; P < 0.0001).
- Multiple regression analysis identified T stage and Ki-67 LI as significant predictors of ADC value.
Conclusions:
- ADC value reflects both the T stage (invasive potential) and Ki-67 LI (proliferative potential) of bladder cancer.
- ADC value shows promise as a biomarker for assessing bladder cancer aggressiveness.
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