Related Experiment Video
Updated: May 12, 2026
07:44
Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Construction of long-wavelength fluorescein analogues and their application as fluorescent probes
Xiaoqing Xiong1, Fengling Song, Gengwen Chen
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116025, PR China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 17, 2013
Abstract:
Born to dye: Five fluorescein analogues were synthesised (see scheme). One analogue was found to emit in the NIR region with a high quantum yield, excellent photostability and good permeability. Three derivatives were found to specifically stain mitochondria and one dye responds to thiols with a strong turn-on NIR fluorescence signal and colorimetric change, in vitro and in vivo.
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