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Total synthesis of (+)-pleuromutilin
Neal J Fazakerley1, Matthew D Helm, David J Procter
1School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 17, 2013
Abstract:
The first enantiospecific total synthesis of the antibacterial natural product (+)-pleuromutilin has been achieved. The approach includes the synthesis of a non-racemic cyclisation substrate from (+)-trans-dihydrocarvone, a highly selective SmI2-mediated cyclisation cascade, an electron transfer reduction of a hindered ester, and the first efficient conversion of (+)-mutilin to the target.
