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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: May 12, 2026

Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages
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Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages

Published on: February 23, 2024

Personalizing oncology: perspectives and prospects.

John Mendelsohn1

  • 1The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 491, Houston, TX 77030-4009, USA. jmendelsohn@mdanderson.org

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 17, 2013
PubMed
Summary
This summary is machine-generated.

Genomically informed methods, or precision cancer medicine, have advanced cancer treatment by targeting therapies to individual patients. Ongoing research continues to refine these targeted approaches, overcoming challenges for better patient outcomes.

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Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Cancer therapy research historically lacked targeted approaches until the 1980s.
  • Advances in understanding cancer's genetic basis and genomic sequencing capabilities have accelerated targeted therapy development.

Purpose of the Study:

  • To provide an overview of the historical research leading to precision cancer medicine.
  • To highlight the progress and remaining challenges in genomically informed cancer therapy.

Main Methods:

  • Review of historical research and clinical trial methodologies in cancer therapy.
  • Analysis of the impact of genetic and molecular target identification.
  • Examination of advancements in genomic sequencing technologies.

Main Results:

  • Significant acceleration in identifying genetic targets and developing biomarker-driven clinical trials since 1980.
  • Genomic sequencing is now feasible within clinically relevant timeframes and costs.
  • Precision cancer medicine enables tailored treatment selection based on individual patient tumor profiles.

Conclusions:

  • Precision cancer medicine, guided by genomic insights, represents a paradigm shift in oncology.
  • Despite progress, challenges persist in target selection, drug design, resistance, and trial complexity.
  • Future research focusing on preselected patients and longitudinal molecular analysis will enhance targeted agent efficacy.