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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

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Biologic complexity in sickle cell disease: implications for developing targeted therapeutics.

Beatrice E Gee¹

¹Department of Pediatrics, Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310-1495, USA. bgee@msm.edu

Thescientificworldjournal

|April 17, 2013

Summary

This summary is machine-generated.

Current sickle cell disease (SCD) therapies are limited. Systems biology approaches reveal complex interactions, suggesting a need to understand multiple pathways for effective treatment development in SCD.

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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

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Published on: June 22, 2012

Area of Science:

Hematology
Systems Biology
Network Medicine

Background:

Current sickle cell disease (SCD) treatments primarily manage complications.
Translating mechanistically based therapies is challenging due to reductionist approaches focusing on single pathways.
SCD pathophysiology involves interacting processes contributing to vaso-occlusion and vasculopathy.

Purpose of the Study:

To model the relationships between sickle hemoglobin (Hb S) polymerization and SCD outcomes using systems biology.
To explore the complex interplay of pathophysiologic processes in SCD.
To highlight the need for a holistic approach in SCD research.

Main Methods:

Applied systems biology and network medicine concepts.
Developed models to illustrate the link between Hb S polymerization and acute pain/chronic vasculopathy.
Analyzed downstream pathways like inflammation and oxidative stress.

Main Results:

Hb S polymerization initiates a cascade of interacting pathophysiologic processes.
Inflammation and oxidative stress are downstream consequences of Hb S polymerization.
Pain in SCD is multifactorial, potentially influenced by factors beyond vascular occlusion.

Conclusions:

A systems biology approach is crucial for understanding SCD's complexity.
Future research must address the intricate biology of SCD and pain.
Demonstrating in vivo relevance of individual pathways is essential before clinical trials.