Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed diagnosis of ocular myasthenia gravis in a patient with aponeurotic ptosis: A case report.

SAGE open medical case reports·2026
Same author

A Validated LC-MS/MS Method for the Determination of Perospirone in Human Plasma and Its Pharmacokinetic Application in Healthy Volunteers.

ACS omega·2026
Same author

NF‑κB signaling drives Th17‑mediated lacrimal gland injury and tear dysfunction in a murine model of primary Sjögren's syndrome.

Molecular medicine reports·2026
Same author

Development and validation of a stability-indicating high-performance liquid chromatography method for iomeprol.

Scientific reports·2026
Same author

Comparison of the somatic mutations in breast carcinomas in sporadic and BRCA1 carrier patients through targeted next generation sequencing.

Human pathology·2026
Same author

Genomic Characterization of Antibiotic-Resistant <i>Enterococcus</i> Spp. Strains in Clinical Settings of Yichang, China.

Infection and drug resistance·2026

Related Experiment Video

Updated: May 12, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress.

Sin Bond Leung1, Huina Zhang, Chi Wai Lau

  • 1School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong.

Evidence-Based Complementary and Alternative Medicine : Ecam
|April 17, 2013
PubMed
Summary

Salidroside protects against cardiovascular dysfunction caused by high homocysteine levels. This natural compound preserves nitric oxide bioavailability by reducing oxidative stress and improving endothelial function.

Related Experiment Videos

Last Updated: May 12, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Area of Science:

  • Cardiovascular Science
  • Oxidative Stress Research
  • Pharmacology

Background:

  • Hyperhomocysteinemia is a risk factor for cardiovascular diseases, linked to increased oxidative stress.
  • Salidroside, from Rhodiola rosea, has known antioxidant and neuroprotective effects.
  • The vascular benefits of salidroside, particularly against endothelial dysfunction, remain largely unexplored.

Purpose of the Study:

  • To investigate the protective effects of salidroside on homocysteine-induced endothelial dysfunction.
  • To explore the mechanisms underlying salidroside's vascular benefits.
  • To assess salidroside's potential in managing oxidative-stress-associated cardiovascular dysfunction.

Main Methods:

  • Functional studies on rat aortas to assess vascular effects.
  • Dihydroethidium (DHE) imaging to quantify reactive oxygen species (ROS) levels.
  • Western blotting to analyze protein expression related to oxidative stress and nitric oxide (NO) bioavailability.

Main Results:

  • Homocysteine impaired endothelium-dependent relaxations in rat aortas, an effect reversed by salidroside pretreatment.
  • Salidroside inhibited homocysteine-induced increases in NOX2 expression and ROS production in aortic tissues and endothelial cells.
  • Salidroside enhanced the phosphorylation of endothelial nitric oxide synthase (eNOS), counteracting homocysteine's inhibitory effect.

Conclusions:

  • Salidroside preserves nitric oxide bioavailability and protects against homocysteine-induced endothelial dysfunction.
  • The protective mechanism involves the inhibition of NOX2 expression and subsequent reduction in ROS production.
  • Salidroside demonstrates therapeutic potential for cardiovascular dysfunction linked to oxidative stress.