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Published on: February 10, 2013
Prognostic value of normal dobutamine stress echocardiography in renal transplant candidates
Nithima Chaowalit1, Maytinee Kittipovanonth, Khemajira Karaketklang
1Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sincw@mahidol.ac.th
Insights
Normal dobutamine stress echocardiography indicates a favorable long-term prognosis for patients awaiting kidney transplants. This cardiac screening tool helps assess cardiovascular risk in high-risk transplant candidates.
Area of Science:
- Cardiology
- Nephrology
- Transplant Medicine
Background:
- Renal transplant candidates face elevated risks of cardiovascular events.
- Pre-operative cardiovascular evaluation lacks a definitive screening tool.
Purpose of the Study:
- To assess the prognostic significance of dobutamine stress echocardiography in renal transplant candidates.
- To determine the value of this non-invasive cardiac test in pre-operative evaluation.
Main Methods:
- Dobutamine stress echocardiography was performed on 107 renal transplant candidates.
- Mean follow-up duration was 2.8 years, with total mortality as the primary endpoint.
Main Results:
- Overall survival probabilities at 1, 3, and 5 years were 87%, 83%, and 79%, respectively.
- For patients who received transplants, survival rates at 1, 3, and 5 years were 100%, 100%, and 89%.
Conclusions:
- A normal dobutamine stress echocardiography result predicts a good long-term prognosis in individuals undergoing renal transplant evaluation.
- This non-invasive test can aid in risk stratification for this high-risk population.
Background:
Renal transplant candidates are at high-risk for cardiovascular events. No definite screening tool has been recommended for the pre-operative evaluation.
Objective:
The authors studied the prognostic value of normal dobutamine stress echocardiography in this population.
Material And Method:
Dobutamine stress echocardiography was performed for the pre-operative assessment in 107 renal transplant candidates (age 53.2 +/- 6.2 years, 66.4% male). The mean follow-up time was 2.8 +/- 1.7 years. The primary endpoint was total mortality.
Results:
During follow-up, 16 (15.0%) died and 26 (24.3%) patients underwent kidney transplantation. The overall survival probabilities at 1, 3 and 5 years were 87, 83 and 79%, respectively. Among those who underwent renal transplantation, the survival probabilities at 1, 3 and 5 years were 100, 100 and 89%, respectively
Conclusion:
In renal transplant candidates, normal dobutamine stress echocardiography portends a good long-term prognosis.
