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Updated: May 12, 2026

Thermal Measurement Techniques in Analytical Microfluidic Devices

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

Understanding the thermodynamic micro-environment inside a pan coater using a data logging device.

Preetanshu Pandey¹, Jiangning Ji, Ganeshkumar Subramanian

¹Drug Product Science and Technology, Bristol-Myers Squibb , New Brunswick, NJ , USA.

Drug Development and Industrial Pharmacy

|April 18, 2013

Summary

This summary is machine-generated.

PyroButtons effectively monitor pan coating microenvironments, correlating relative humidity (RH) with defects like logo-bridging. This technology aids in defining critical process parameters for optimal tablet coating.

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Area of Science:

Pharmaceutical Technology
Process Engineering
Materials Science

Background:

Pan coating is crucial for pharmaceutical tablet finishing.
Monitoring the microenvironment within the pan coater is essential for consistent coating quality.
Traditional methods may not capture the dynamic conditions experienced by the tablets.

Purpose of the Study:

To validate the use of PyroButton data-loggers for monitoring pan coating thermodynamic conditions.
To quantify temperature and humidity variations during the coating process.
To correlate environmental data with coating defects.

Main Methods:

PyroButtons were deployed at static and dynamic locations within a 24-inch pan coater.
A full factorial design of experiments varied exhaust temperature, pan speed, and spray rate.
Coating performance was assessed, noting defects such as logo-bridging.

Main Results:

PyroButtons provided detailed signatures of the coating process, showing tablet-bed temperature and humidity differentials relative to exhaust conditions.
Tablet-bed temperature was consistently lower than exhaust temperature, influenced by spray rate.
Tablet-bed humidity was consistently higher than exhaust humidity.
Relative humidity (RH) within the tablet bed correlated with logo-bridging defects, establishing a critical threshold of 30% RH.

Conclusions:

PyroButtons offer valuable microenvironmental data for pan coating processes.
This data can be directly correlated with specific coating defects like logo-bridging.
The technology facilitates the establishment of a robust process design space for diverse coating and tablet formulations.