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Updated: May 12, 2026

Standards for Quantitative Metalloproteomic Analysis Using Size Exclusion ICP-MS
Published on: April 13, 2016
Obesity and metallothionein
Masao Sato, Takashige Kawakami, Yoshito Kadota
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan. msato@ph.bunri-u.ac.jp.
Metallothionein (MT) is induced in adipose tissue during obesity development and may prevent obesity in female mice. MT might suppress oxidative stress and endoplasmic reticulum stress, offering potential for obesity-related disease treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Metabolic Diseases
Background:
- Obesity development involves adipocyte differentiation, maturation, and lipid accumulation.
- Metallothionein (MT) is a protein known for its role in metal detoxification and antioxidant defense.
- MT expression is observed in adipose tissue during obesity development.
Purpose of the Study:
- To review the potential role of metallothionein (MT) in adipose tissue concerning obesity development.
- To explore MT's preventive effects against obesity and its underlying mechanisms.
Main Methods:
- Literature review focusing on studies investigating metallothionein in adipose tissue.
- Analysis of existing research on MT induction during obesity and its effects in animal models.
- Examination of potential molecular mechanisms, including the role of MEST/Peg1.
Main Results:
- Metallothionein (MT) is induced in adipose tissue as obesity develops.
- MT demonstrates a preventive role in obesity, particularly observed in female mice.
- Potential mechanisms involve suppression of superoxide generation and endoplasmic reticulum stress.
Conclusions:
- Metallothionein (MT) may play a protective role against obesity development and related pathologies.
- Further research into MT inducers could lead to clinical applications for obesity-related diseases.
- Understanding MT's interaction with factors like MEST/Peg1 is crucial for elucidating its anti-obesity effects.
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