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Temperature-sensitive adenosine-mediated vasoconstriction in the skin microcirculation.

I Stojanov¹, K G Proctor

¹Department of Physiology, University of Tennessee Health Science Center, Memphis.

The Journal of Pharmacology and Experimental Therapeutics

|June 1, 1990

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Adenosine receptors (A1) in hamster skin arterioles show temperature-dependent vasoconstriction. This suggests temperature sensitivity is key for classifying adenosine receptors.

Area of Science:

Pharmacology
Physiology
Microcirculation

Background:

Adenosine receptors (A1 and A2) play crucial roles in regulating vascular tone.
Understanding the influence of temperature on adenosine receptor function is vital for interpreting physiological responses.

Purpose of the Study:

To investigate the effect of local skin temperature on adenosine receptor-mediated vasoconstriction and vasodilation in hamster arterioles.
To determine if A1 and A2 adenosine receptors exhibit temperature-dependent activity in vivo.

Main Methods:

Topical application of adenosine receptor agonists (e.g., adenosine, N6-cyclohexyladenosine) to arterioles in hamster skin microcirculation.
Vascular responses (vasoconstriction/vasodilation) were measured at varying local skin temperatures.

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Main Results:

A1 receptor-mediated vasoconstrictions were enhanced by increased temperature and unaffected by decreased temperature.
Norepinephrine and angiotensin II responses showed different temperature dependencies, with angiotensin II being temperature-insensitive.
Adenosine-induced vasodilation was generally temperature-insensitive, with exceptions at higher concentrations.

Conclusions:

A1 adenosine receptors, but not A2 receptors, demonstrate temperature-dependent actions in vivo.
Temperature sensitivity may serve as an additional criterion for classifying adenosine receptors.
These findings highlight the complex interplay between temperature and receptor pharmacology in microvascular regulation.