Related Experiment Video
Updated: May 12, 2026
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Molecularly targeted therapies for melanoma
Lucinda S Liu1, Oscar R Colegio
1Department of Dermatology, Yale School of Medicine, New Haven, CT 06520-8059, USA.
International Journal of Dermatology
|April 18, 2013
Summary
Targeted therapies offer a new approach to managing skin cancers, particularly melanoma. This review covers molecular pathways and new drugs like vemurafenib, imatinib, and ipilimumab for advanced melanoma.
Area of Science:
- Oncology
- Dermatology
- Molecular Biology
Background:
- Skin cancers, especially melanoma, pose significant management challenges.
- Targeted therapies represent a paradigm shift in cancer treatment.
- Understanding melanoma's molecular underpinnings is crucial for developing effective therapies.
Purpose of the Study:
- To review critical molecular pathways in melanoma development.
- To discuss novel pharmacologic agents designed to target these pathways.
- To provide an overview of vemurafenib, imatinib, and ipilimumab for advanced melanoma.
Main Methods:
- Literature review of molecular pathways in melanoma.
- Analysis of pharmacologic agents targeting identified pathways.
- Review of clinical applications of specific targeted therapies.
Main Results:
- Key molecular pathways driving melanoma progression have been identified.
- Several novel targeted agents show promise in preclinical and clinical studies.
- Vemurafenib, imatinib, and ipilimumab are highlighted for metastatic or unresectable melanoma.
Conclusions:
- Targeted therapies are a rational and emerging approach for skin cancer management.
- Pharmacologic agents targeting specific molecular pathways offer new hope for melanoma patients.
- Continued research into molecular pathways and targeted agents is essential for advancing melanoma treatment.
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