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Platelets and atherothrombosis: causes, targets and treatments for thrombosis

T I Siddiqui1, A Kumar K S, D K Dikshit

  • 1Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, M.G. Marg, Lucknow-226 001, India.

Current Medicinal Chemistry
|April 18, 2013
PubMed

Insights

Arterial thrombosis, a complication of atherosclerosis causing heart attack and stroke, involves platelets. Understanding platelet mechanisms can lead to new antiplatelet therapies for cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Pathophysiology

Background:

  • Atherosclerosis leads to arterial thrombosis, a major cause of mortality globally, responsible for heart attack and stroke.
  • Cardiovascular diseases affect millions, with a significant portion at high risk for arterial thrombosis.
  • Platelets are crucial in atherogenesis and thrombus formation due to their adhesive and activation properties.

Purpose of the Study:

  • To review the phenomenon of hemostasis and the central role of platelets in atherothrombosis.
  • To explore the mechanisms of platelet interaction with vascular surfaces and aggregation.
  • To briefly examine the efficacy of current antiplatelet agents.

Main Methods:

  • Review of existing literature on hemostasis, atherosclerosis, and thrombosis.
  • Analysis of the role of platelets in the pathological processes of atherothrombosis.
  • Summary of findings on antiplatelet agent efficacy.

Main Results:

  • Platelet activation and aggregation are central to the development of arterial thrombosis.
  • Understanding platelet function provides insights into potential therapeutic targets.
  • Current antiplatelet agents show varying efficacy in managing atherothrombotic events.

Conclusions:

  • Targeting platelet pathways offers a promising strategy for preventing and treating atherothrombosis.
  • Further research into platelet mechanisms is essential for developing more effective antiplatelet therapies.
  • Selective inhibition of pathological platelet pathways could reduce mortality from cardiovascular diseases.

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