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Serum paraoxonase activity and oxidative status in subjects with alopecia areata
Serap Gunes Bilgili1, Halil Ozkol, Ayse Serap Karadag
1Department of Dermatology, Yuzuncu Yil University, Van 65100, Turkey. drserapgunes@yahoo.com
Introduction:
Previous studies have suggested that oxidative stress may play an important role in the pathogenesis of alopecia areata (AA) but these reports are limited and conflicting.
Objectives:
The aim of this study was to investigate serum paraoxonase-1 (PON1) activity and oxidative status in subjects with AA.
Materials And Methods:
Thirty-nine subjects with AA and 39 healthy controls were enrolled. Serum PON1 activity, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined.
Results:
Serum TAC levels and PON1 activity were significantly lower in the subjects with AA than controls (p = 0.038, p = 0.001, respectively), whereas TOS levels and OSI were significantly higher (both, p = 0.001) in the subjects with AA.
Conclusions:
Our results suggest that reduced PON1 activity may be related to increased oxidant and decreased antioxidant levels. These data indicated that oxidant/antioxidant imbalance may play a role in the etiopathogenesis of AA.
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